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The HPE ProLiant DL380 Gen10 12×3.5″ Server is Hewlett Packard Enterprise’s most trusted and versatile 2U rack server, designed to deliver a perfect balance of security, performance, and scalability. Built with the latest Intel® Xeon® Scalable Processors, high-speed DDR4 SmartMemory, and support for Intel Optane™ persistent memory, this server provides a future-proof foundation for modern workloads ranging from virtualization and cloud computing to AI, analytics, and mission-critical databases.
With its flexible 12×3.5″ LFF drive bay chassis, the HPE DL380 Gen10 offers high storage capacity with the ability to expand as your business grows. It is backed by a comprehensive 3/3/3 warranty and HPE’s world-class support services, making it one of the most reliable solutions for enterprise IT environments. The HPE ProLiant DL380 Gen10 12×3.5″ Server is engineered to reduce total cost of ownership while delivering enterprise-grade resilience.
HPE Trusted Supply Chain ensures protection against malicious firmware and counterfeit components.
Secure manufacturing process in hardened HPE facilities.
End-to-end inspection for maximum data integrity and authenticity.
Supports 1 or 2 Intel® Xeon® Scalable processors with up to 28 cores each.
Up to 3.0 TB DDR4 SmartMemory or 6.0 TB with HPE Persistent Memory.
Up to 60% performance gain and 27% more cores compared to previous generations.
12x 3.5″ LFF drive bays with support for SAS, SATA, and SSD options.
Optional NVMe drives for ultra-low latency workloads.
Expandable chassis supports multiple configurations including GPUs and networking cards.
Support for up to 7x NVIDIA Tesla T4 GPUs or 7x Xilinx Alveo U50 accelerators.
Perfect for AI, deep learning, VDI, rendering, and high-performance computing (HPC).
The HPE ProLiant DL380 Gen10 12×3.5″ Server is powered by the Intel® Xeon® Scalable processor family, enabling organizations to scale performance seamlessly. With support for up to 56 cores in a dual-socket configuration, the system is built to handle demanding enterprise workloads.
24 DIMM slots with HPE DDR4 SmartMemory.
Intel Optane™ persistent memory 100 series for hybrid memory and fast storage.
Memory speed up to 2933 MT/s for faster data access.
This combination of compute and memory makes the server ideal for:
In-memory databases (SAP HANA, Oracle, SQL)
Virtualization platforms with high VM density
Business-critical ERP and CRM applications
AI and deep learning training models
The HPE ProLiant DL380 Gen10 12×3.5″ Server empowers organizations to optimize IT resources while preparing for next-generation workloads.
The 12×3.5″ chassis design gives enterprises the flexibility to choose between high-capacity storage or performance-optimized NVMe SSDs.
Support for 12 LFF drives (SAS/SATA/SSD).
Optional rear drive bays for additional storage (2–3 LFF or 6 SFF).
20 NVMe drives supported for latency-sensitive workloads.
Integrated HPE Smart Array Controllers with support for RAID and HBA modes.
Dual M.2 SSDs for OS boot redundancy.
With this flexibility, businesses can architect the server for:
Database-heavy environments needing terabytes of raw storage.
Hybrid workloads requiring both HDD capacity and SSD speed.
Virtualization clusters demanding high I/O throughput.
The HPE ProLiant DL380 Gen10 12×3.5″ Server offers a choice between Embedded LOM (4x1GbE) or Networking Choice (NC) models for maximum flexibility.
HPE FlexibleLOM adapters support 1GbE, 10GbE, 25GbE, 40GbE, and 100GbE options.
Up to 8 PCIe expansion slots for NICs, HBAs, GPUs, and storage controllers.
Balanced architecture ensures low-latency data movement across workloads.
HPE integrates advanced automation and security features in the DL380 Gen10 to simplify IT operations.
HPE iLO 5 with features like:
Security Dashboard
Workload Performance Advisor
Server Configuration Lock
HPE OneView for unified infrastructure management.
HPE InfoSight for AI-driven analytics and proactive issue prevention.
TPM 2.0 and intrusion detection for hardware-level security.
This intelligent management ensures that IT teams can reduce downtime, increase efficiency, and safeguard workloads.
The HPE ProLiant DL380 Gen10 12×3.5″ Server is compatible with a wide range of OS and virtualization platforms:
Microsoft Windows Server (2016, 2019, 2022)
VMware vSphere / ESXi
Red Hat Enterprise Linux (RHEL)
SUSE Linux Enterprise Server (SLES)
Oracle Linux and Oracle VM
Ubuntu Server
Citrix XenServer
Cloud-native platforms like Docker and Azure Stack HCI
The adaptability of the HPE ProLiant DL380 Gen10 12×3.5″ Server makes it a perfect fit for:
Data-intensive applications (databases, ERP, CRM).
AI and deep learning workloads leveraging GPU acceleration.
High-performance computing (HPC) clusters.
Cloud and virtualization infrastructures.
Big Data analytics and business intelligence.
File and object storage platforms.
Industry’s most trusted compute platform with proven reliability.
Future-ready scalability with Intel Xeon Scalable CPUs and Intel Optane memory.
Flexible storage supporting HDDs, SSDs, and NVMe.
Comprehensive security with HPE Trusted Supply Chain and iLO 5.
Optimized for AI, cloud, and enterprise workloads.
Backed by HPE’s global support and 3/3/3 warranty.
The HPE ProLiant DL380 Gen10 12×3.5″ Server is the ultimate enterprise server solution, delivering unmatched performance, security, and expandability. Whether you’re running AI models, mission-critical databases, or hybrid cloud environments, this server provides the reliability and scalability that modern businesses demand.
With its flexible 12×3.5″ chassis design, support for Intel Xeon Scalable processors, Intel Optane memory, and HPE Trusted Supply Chain security, the DL380 Gen10 remains the gold standard for enterprise IT infrastructure. By choosing the HPE ProLiant DL380 Gen10 12×3.5″ Server, organizations can secure their IT investment while preparing for the challenges of tomorrow.
| Form factor |
2U |
|---|---|
| Processor |
Intel® Xeon® Scalable processors. |
| No. of processor socket |
2 |
| Ram type |
DDR4 |
| Total Memory slots |
24 DIMM slots |
| Max memory |
Up to 3 TB DDR4 2933 MT/s |
| PCIe slots |
8 PCIe 3.0 slots |
| Support hard drive |
12 LFF SAS, SATA, and NVMe |
| Support raid controller |
-Software RAID |
| Network controller |
1x Embedded 4 x 1GbE Network Adapter |
| I/O Port |
-Serial : Optional, rear |
| Power supply |
500W , 800W , 1600W Platinum |
| Remote management |
HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download); HPE iLO Advanced, HPE iLO Advanced Premium Security Edition and |
| Operating system |
Windows Server |
| Dimensions |
Height : 8.73 cm(3.44 in) |
| Weight |
Max : 24.5 kg (54 lbs) |
| Operation temperature |
10°C to 35°C (50°F to 95°F) |
The HPE ProLiant DL380 Gen10 12×3.5″ Server is Hewlett Packard Enterprise’s most trusted and versatile 2U rack server, designed to deliver a perfect balance of security, performance, and scalability. Built with the latest Intel® Xeon® Scalable Processors, high-speed DDR4 SmartMemory, and support for Intel Optane™ persistent memory, this server provides a future-proof foundation for modern workloads ranging from virtualization and cloud computing to AI, analytics, and mission-critical databases.
With its flexible 12×3.5″ LFF drive bay chassis, the HPE DL380 Gen10 offers high storage capacity with the ability to expand as your business grows. It is backed by a comprehensive 3/3/3 warranty and HPE’s world-class support services, making it one of the most reliable solutions for enterprise IT environments. The HPE ProLiant DL380 Gen10 12×3.5″ Server is engineered to reduce total cost of ownership while delivering enterprise-grade resilience.
HPE Trusted Supply Chain ensures protection against malicious firmware and counterfeit components.
Secure manufacturing process in hardened HPE facilities.
End-to-end inspection for maximum data integrity and authenticity.
Supports 1 or 2 Intel® Xeon® Scalable processors with up to 28 cores each.
Up to 3.0 TB DDR4 SmartMemory or 6.0 TB with HPE Persistent Memory.
Up to 60% performance gain and 27% more cores compared to previous generations.
12x 3.5″ LFF drive bays with support for SAS, SATA, and SSD options.
Optional NVMe drives for ultra-low latency workloads.
Expandable chassis supports multiple configurations including GPUs and networking cards.
Support for up to 7x NVIDIA Tesla T4 GPUs or 7x Xilinx Alveo U50 accelerators.
Perfect for AI, deep learning, VDI, rendering, and high-performance computing (HPC).
The HPE ProLiant DL380 Gen10 12×3.5″ Server is powered by the Intel® Xeon® Scalable processor family, enabling organizations to scale performance seamlessly. With support for up to 56 cores in a dual-socket configuration, the system is built to handle demanding enterprise workloads.
24 DIMM slots with HPE DDR4 SmartMemory.
Intel Optane™ persistent memory 100 series for hybrid memory and fast storage.
Memory speed up to 2933 MT/s for faster data access.
This combination of compute and memory makes the server ideal for:
In-memory databases (SAP HANA, Oracle, SQL)
Virtualization platforms with high VM density
Business-critical ERP and CRM applications
AI and deep learning training models
The HPE ProLiant DL380 Gen10 12×3.5″ Server empowers organizations to optimize IT resources while preparing for next-generation workloads.
The 12×3.5″ chassis design gives enterprises the flexibility to choose between high-capacity storage or performance-optimized NVMe SSDs.
Support for 12 LFF drives (SAS/SATA/SSD).
Optional rear drive bays for additional storage (2–3 LFF or 6 SFF).
20 NVMe drives supported for latency-sensitive workloads.
Integrated HPE Smart Array Controllers with support for RAID and HBA modes.
Dual M.2 SSDs for OS boot redundancy.
With this flexibility, businesses can architect the server for:
Database-heavy environments needing terabytes of raw storage.
Hybrid workloads requiring both HDD capacity and SSD speed.
Virtualization clusters demanding high I/O throughput.
The HPE ProLiant DL380 Gen10 12×3.5″ Server offers a choice between Embedded LOM (4x1GbE) or Networking Choice (NC) models for maximum flexibility.
HPE FlexibleLOM adapters support 1GbE, 10GbE, 25GbE, 40GbE, and 100GbE options.
Up to 8 PCIe expansion slots for NICs, HBAs, GPUs, and storage controllers.
Balanced architecture ensures low-latency data movement across workloads.
HPE integrates advanced automation and security features in the DL380 Gen10 to simplify IT operations.
HPE iLO 5 with features like:
Security Dashboard
Workload Performance Advisor
Server Configuration Lock
HPE OneView for unified infrastructure management.
HPE InfoSight for AI-driven analytics and proactive issue prevention.
TPM 2.0 and intrusion detection for hardware-level security.
This intelligent management ensures that IT teams can reduce downtime, increase efficiency, and safeguard workloads.
The HPE ProLiant DL380 Gen10 12×3.5″ Server is compatible with a wide range of OS and virtualization platforms:
Microsoft Windows Server (2016, 2019, 2022)
VMware vSphere / ESXi
Red Hat Enterprise Linux (RHEL)
SUSE Linux Enterprise Server (SLES)
Oracle Linux and Oracle VM
Ubuntu Server
Citrix XenServer
Cloud-native platforms like Docker and Azure Stack HCI
The adaptability of the HPE ProLiant DL380 Gen10 12×3.5″ Server makes it a perfect fit for:
Data-intensive applications (databases, ERP, CRM).
AI and deep learning workloads leveraging GPU acceleration.
High-performance computing (HPC) clusters.
Cloud and virtualization infrastructures.
Big Data analytics and business intelligence.
File and object storage platforms.
Industry’s most trusted compute platform with proven reliability.
Future-ready scalability with Intel Xeon Scalable CPUs and Intel Optane memory.
Flexible storage supporting HDDs, SSDs, and NVMe.
Comprehensive security with HPE Trusted Supply Chain and iLO 5.
Optimized for AI, cloud, and enterprise workloads.
Backed by HPE’s global support and 3/3/3 warranty.
The HPE ProLiant DL380 Gen10 12×3.5″ Server is the ultimate enterprise server solution, delivering unmatched performance, security, and expandability. Whether you’re running AI models, mission-critical databases, or hybrid cloud environments, this server provides the reliability and scalability that modern businesses demand.
With its flexible 12×3.5″ chassis design, support for Intel Xeon Scalable processors, Intel Optane memory, and HPE Trusted Supply Chain security, the DL380 Gen10 remains the gold standard for enterprise IT infrastructure. By choosing the HPE ProLiant DL380 Gen10 12×3.5″ Server, organizations can secure their IT investment while preparing for the challenges of tomorrow.
| Form factor |
2U |
|---|---|
| Processor |
Intel® Xeon® Scalable processors. |
| No. of processor socket |
2 |
| Ram type |
DDR4 |
| Total Memory slots |
24 DIMM slots |
| Max memory |
Up to 3 TB DDR4 2933 MT/s |
| PCIe slots |
8 PCIe 3.0 slots |
| Support hard drive |
12 LFF SAS, SATA, and NVMe |
| Support raid controller |
-Software RAID |
| Network controller |
1x Embedded 4 x 1GbE Network Adapter |
| I/O Port |
-Serial : Optional, rear |
| Power supply |
500W , 800W , 1600W Platinum |
| Remote management |
HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download); HPE iLO Advanced, HPE iLO Advanced Premium Security Edition and |
| Operating system |
Windows Server |
| Dimensions |
Height : 8.73 cm(3.44 in) |
| Weight |
Max : 24.5 kg (54 lbs) |
| Operation temperature |
10°C to 35°C (50°F to 95°F) |
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