HPE ProLiant DL380 Gen10 8×2.5″ Server – Secure, Scalable, and Enterprise-Ready

The HPE ProLiant DL380 Gen10 8×2.5″ Server is a highly flexible and secure enterprise server built on Hewlett Packard Enterprise’s most trusted platform. Featuring Intel® Xeon® Scalable processors, support for HPE DDR4 SmartMemory and Intel Optane™ persistent memory, this compact 2U server delivers outstanding performance, scalability, and reliability for modern IT workloads.

Designed with 8×2.5″ SFF bays, the HPE DL380 Gen10 offers enterprises the ability to balance performance-oriented SSDs with high-capacity HDDs and optional NVMe drives for demanding workloads. It is ideal for virtualization, cloud computing, AI, and mission-critical business applications.

The HPE ProLiant DL380 Gen10 8×2.5″ Server stands out as a cost-effective yet enterprise-class solution, combining high compute density with strong security and advanced management capabilities.

Key Features

Defend Applications and Data Before Your Server is Built

• HPE Trusted Supply Chain safeguards servers against malicious microcode and counterfeit components.

• Manufactured in secure HPE facilities with end-to-end inspection.

• Protects sensitive applications and workloads throughout the server lifecycle.

World-Class Performance

• Powered by 1 or 2 Intel® Xeon® Scalable processors with up to 28 cores each.

• Delivers up to 60% performance gains and 27% more cores over previous generations.

• Supports HPE DDR4 SmartMemory up to 3.0 TB, or 6.0 TB with Intel Optane™ persistent memory.

Enhanced GPU Density

• Supports up to 7x NVIDIA Tesla T4 GPUs or Xilinx Alveo accelerators.

• Optimized for AI inferencing, deep learning, rendering, VDI, and HPC workloads.

Performance and Scalability

The HPE ProLiant DL380 Gen10 8×2.5″ Server provides unmatched scalability, making it the perfect fit for growing enterprises.

Processor Architecture

• Up to 56 cores in a dual-socket configuration.

• Wide range of Xeon series supported (8100/8200, 6100/6200, 5100/5200, etc.).

• Processor speeds up to 3.9 GHz with large cache sizes (8.25 MB – 38.5 MB).

Memory Flexibility

• 24 DIMM slots with DDR4 SmartMemory.

• Intel Optane Persistent Memory Series 100 support for hybrid workloads.

• Delivers faster analytics, in-memory database performance, and real-time insights.

With these capabilities, the HPE ProLiant DL380 Gen10 8×2.5″ Server ensures enterprises can scale compute and memory resources based on workload demands.

Storage and Expansion

The 8×2.5″ SFF chassis provides the right mix of performance and capacity for enterprises.

• Supports up to 8 SFF SAS/SATA/SSD drives.

• Optional rear drives allow further expansion (2–6 SFF or 2 Dual UFF).

• Up to 20 NVMe drives for latency-sensitive workloads.

• Integrated HPE Smart Array Controllers with both RAID and HBA modes.

• Dual M.2 SATA SSDs for OS boot reliability.

This storage design makes the server well-suited for:

• Database acceleration with SSD/NVMe.

• Virtualization clusters requiring fast I/O.

• Hybrid workloads needing both HDD capacity and SSD performance.

Networking and Connectivity

The HPE ProLiant DL380 Gen10 8×2.5″ Server offers enterprises advanced networking options for flexible deployments.

• Embedded 4x1GbE LOM as standard.

• Networking Choice (NC) models allow custom NIC selection.

• HPE FlexibleLOM adapters with 1GbE – 100GbE options.

• Up to 8 PCIe expansion slots for networking, GPUs, and storage controllers.

This flexibility ensures low-latency, high-bandwidth connections for data-intensive workloads.

Management and Security

HPE integrates enterprise-grade management and security into the DL380 Gen10 platform.

• HPE iLO 5 for intelligent monitoring and server health management.

• Security features include:

  • Server Configuration Lock

  • iLO Security Dashboard

  • Workload Performance Advisor

• HPE OneView provides centralized IT infrastructure management.

• HPE InfoSight delivers AI-driven analytics for predictive maintenance.

• Optional TPM 2.0 and intrusion detection enhance hardware-level protection.

Operating System Support

The HPE ProLiant DL380 Gen10 8×2.5″ Server supports a wide range of operating systems and hypervisors:

• Microsoft Windows Server 2016, 2019, 2022

• VMware vSphere / ESXi

• Red Hat Enterprise Linux (RHEL)

• SUSE Linux Enterprise Server (SLES)

• Ubuntu Server

• Oracle Linux / Oracle VM

• Citrix XenServer

• Container and cloud-native platforms like Docker and Azure Stack HCI

Use Cases

The compact yet powerful HPE ProLiant DL380 Gen10 8×2.5″ Server is perfect for:

• Small to mid-sized databases.

• Virtualization and VDI environments.

• AI inferencing and deep learning workloads.

• Cloud-native applications.

• Business-critical enterprise workloads (ERP, CRM).

• Edge and remote office deployments.

Why Choose HPE ProLiant DL380 Gen10 8×2.5″ Server?

• Compact 8-bay SFF chassis for performance-driven storage.

• Enterprise-class reliability with HPE Trusted Supply Chain.

• Scalable compute power with Intel Xeon Scalable processors.

• Flexible networking up to 100GbE.

• GPU-ready platform for AI and HPC workloads.

• Comprehensive HPE support and 3/3/3 warranty.

Conclusion

The HPE ProLiant DL380 Gen10 8×2.5″ Server delivers an unbeatable combination of performance, security, and scalability in a compact 2U form factor. With its 8×2.5″ SFF storage bays, enterprises can customize deployments for SSD speed, HDD capacity, or NVMe acceleration.

Backed by Intel Xeon Scalable processors, HPE SmartMemory, and Optane Persistent Memory, this server ensures optimal performance for a variety of workloads. Whether deployed for databases, virtualization, AI, or enterprise applications, the HPE ProLiant DL380 Gen10 8×2.5″ Server remains a future-proof investment that grows with your business.

Check full specs and datasheet below: Spec sheet